Results of assessment of the therapeutic effectiveness of treatment regimens for mycosis mastitis

The purpose of the study was to establish the comparative effectiveness of the used schemes for the treatment of mycotic mastitis in cows in the Kamyshin district of the Volgograd region. The object of research are dairy cows diagnosed with mycotic mastitis. The diagnosis of mycotic mastitis was based on mycological studies of secretions from the quarters affected by the pathological process. The cows of the second experimental group were treated with Thioconazole and Kerbamint gel.

Introduction. The purpose of the study was to establish the comparative effectiveness of the used schemes for the treatment of mycotic mastitis in cows in the Kamyshin district of the Volgograd region.

Object. The object of research is dairy cows diagnosed with mycotic mastitis.

Material and methods. The diagnosis of mycotic mastitis was based on mycological studies of secretions from the quarters affected by the pathological process. The results of the clinical study consisted of examination and palpation, as well as analysis of the quality of milk, taking into account its macroscopic changes. For the treatment of cows of the first experimental group (n=10), a local application of the antifungal emulsion «DC - Decamethoxin and Clotrimazole» was used. The cows of the second experimental group (n=10) were treated with Thioconazole and Kerbamint gel. The third group was the control (n=10). The results were subjected to statistical processing in the Biostat 3.0 program.

Results and conclusions. All 100% of the cows of the experimental groups had clinical signs, such as a swollen udder with heat and pain when touched. Reference intervals for all variables: Wood and Quirosh-Roche were found among leukocytes, segmented and stab neutrophils. The median and frequency distributions of all components of the leukogram differed significantly between the two groups (P<0.01, ANOVA, Mann-Whitney U-test) occurred among eosinophils and basophils. When using the drug Thioconazole + Kerbamint, recovery in the 2^nd experimental group occurred 0.2 days earlier than recovery in the 1st experimental group using the drug - the antifungal emulsion «DC - Decamethoxin and Clotrimazole». When using an antifungal emulsion in the 1st experimental group for the treatment of the antifungal emulsion «DC - Decamethoxin and Clotrimazole», the economic efficiency per ruble of costs was 22.77 rubles. When used in the 2nd experimental group for the treatment of Thioconazole and Kerbamint, the economic efficiency per ruble of costs was 22.07 rubles.

1. Intrauterine infections in cattle of the Volgograd region / G. M. Firsov, A. A. Ryadnov, S. A. Akimova [et al.] // Agrarian Russia. 2023. No. 1. Pр. 40-43.

2. The role of the pathology of childbirth in the mechanism of development of metritis of infectious etiology in cows and a decrease in the sanitary quality of milk / S. O. Loshchinin, G. M. Firsov, A. V. Filatova, V. T. Akhmadov // Nauchnaya zhizn. 2022. V. 17. No. 1 (121). Pр. 114-125.

3. Abebe R. Incidence rate, risk factors, and bacterial causes of clinical mastitis on dairy farms in Hawassa City, southern Ethiopia //Scientific Reports. 2023. V. 13. No 1. Pр. 10945.

4. De Jong E. Selective treatment of nonsevere clinical mastitis does not adversely affect cure, somatic cell count, milk yield, recurrence, or culling: A systematic review and meta-analysis // Journal of Dairy Science. 2022. No 15. Pр. 25.

5. Goulart D. B., Mellata M. Escherichia coli mastitis in dairy cattle: etiology, diagnosis, and treatment challenges // Frontiers in Microbiology. 2022. V. 13. Pр. 928346.

6. Gu Z. A Comparison of Cefquinome Sulfate and Lincomycin Hydrochloride in the Treatment of Mastitis for Lactating Cows // Indian Journal of Animal Research. V. 1. P. 4.

7. Guzmán-Luna P. Quantifying current and future raw milk losses due to bovine mastitis on European dairy farms under climate change scenarios // Science of the Total Environment. 2022. V. 833. Pр. 155149.

8. Hu X. The rumen microbiota contributes to the development of mastitis in dairy cows // Microbiology spectrum. 2022. V. 10. No 1. P. e02512-21.

9. Kovačević Z. Pharmacoeconomic Analysis of the Different Therapeutic Approaches in Control of Bovine Mastitis: Phytotherapy and Antimicrobial Treatment // Antibiotics. 2022. V. 12. No 1. P. 11.

10. Milk quality and its suitability for technological processing in cows with metritis / A. S. Ryhlov, S. O. Loschinin, A. V. Filatova [et al.] // IOP Conference Series: Earth and Environmental Science, Michurinsk, 2021. P. 012101.

11. Neculai-Valeanu A. S., Ariton A. M. Udder health monitoring for prevention of bovine mastitis and improvement of milk quality // Bioengineering. 2022. V. 9. No 11. P. 608.

12. Negash S. Review on bovine mastitis and assessments of its associated risk factors in lactating dairy cows // Int. J. Adv. Res. Biol. Sci. 2023. V. 10. No 3. P. 59-65.

13. Sigmund M. The effect of antibiotic versus no treatment at dry-off on udder health and milk yield in subsequent lactation: A retrospective analysis of Austrian health recording data from dairy herds // Journal of Dairy Science. 2023. V. 106. N. 1. Pр. 452-461.

14. Tabery J. Evaluation of mammary gland health in dairy cows treated by pegylated granulocyte colony-stimulating factor // Acta Veterinaria Brno. 2023. V. 92. No 1. Pр. 3-9.

15. Tommasoni C. Mastitis in Dairy Cattle: On-Farm Diagnostics and Future Perspectives // Animals. 2023. V. 13. No 15. P. 2538.