Biomedical research to study the effect on the lipid level of vegetable oil with a reduced content of glycidyl esters

According to the results of biomedical studies, it was found that the consumption of vegetable oil with a reduced content of glycidyl esters and standard vegetable oil leads to unidirectional changes in the body of laboratory animals – the relative weight of the liver increases, the phenomena of dystrophy and multifocal necrosis of hepatocytes are observed, the level of triglycerides increases when twin hyperlipidemia is induced.

Introduction. The article examines the effect on the lipid level of vegetable oil with a reduced content of glycidyl esters in comparison with standard vegetable oil. These objects were fed to outbred Wistar laboratory rats for 1 month (30 days). A total of 48 outbred male Wistar laboratory rats were used in the experiment. There are 16 animals in each study group.

Materials and methods. In both study groups that received vegetable oil with a reduced content of glycidyl esters and standard vegetable oil, the absolute figures of the background content of total cholesterol, low-density lipoproteins and the atherogenicity index slightly increased compared to animals that received standard complete feed, however, these differences are statistically unreliable. The background level of triglycerides does not differ in all the studied groups.

Results and conclusions. The presented results indicate that there is a statistically significant increase in the level of triglycerides in both study groups compared to animals receiving standard full-fledged feed. In all the studied groups, the total cholesterol content remains at the same level. In both groups studied, the absolute figures of the background content of low-density lipoproteins and the atherogenicity index slightly increased compared to animals receiving standard full-fledged feed, however, these differences are statistically unreliable, as evidenced by the significance levels of p. Thus, according to the results of biomedical studies, it was found that the consumption of vegetable oil with a reduced content of glycidyl esters and standard vegetable oil leads to unidirectional changes in the body of laboratory animals – the relative weight of the liver increases, the phenomena of dystrophy and multifocal necrosis of hepatocytes are observed, the level of triglycerides increases when twin hyperlipidemia is induced.

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